MAJIQlopedia

MAJIQlopedia catalogs and quantifies RNA splicing variations across 86 human tissues and 41 cancer types using RNA-Sequencing (RNA-Seq) data.

Key Features:

• Comprehensive Data Coverage: Includes data from 86 human tissues and 41 cancer types and reports 486,175 annotated and unannotated splicing events in normal tissues and 338,317 events in cancers.
• Quantification of Junction Usage: Reports quantification of splice junction usage across the included tissue and cancer types derived from RNA-Seq.
• Case Studies and Novel Discoveries: Documents tissue- or cancer-specific splicing patterns in WT1, MAPT, and BIN1, identifies novel splicing events in FDX1 and MEGF9 in normal tissues, and reports a cancer-specific exon inclusion event in RPS6KA6 present in two cancer types.

Scientific Applications:

• Splicing landscape analysis: Enables analysis of RNA splicing variation for specific genes and across broader genomic contexts.
• Tissue- and cancer-specific isoform studies: Supports investigations of tissue- and cancer-specific splice isoform usage.
• Discovery of disease-associated events: Aids identification of novel splicing events that may inform disease mechanisms and therapeutic targets.

Methodology:

Quantifies alternative splice junctions from RNA-Sequencing (RNA-Seq) data and integrates both annotated and unannotated splicing events.