MANTA_DB

MANTA_DB correlates microbiota composition with host phenotypic traits to enable integrative analysis of microbial community–phenotype relationships.


Key Features:

  • Integrative Database: Centralized storage and management of microbiota and phenotypic datasets to enable joint analyses of microbial abundances and host traits.
  • Correlation Analysis: Statistical identification of significant associations between microbial abundances and host phenotypic variables.
  • Computational Mapping and Interpretation: Analytical procedures to map, analyze, and interpret relationships between microbiota composition and host phenotypes rather than focusing solely on taxonomic profiling or group comparisons.

Scientific Applications:

  • Correlation discovery: Identification of significant correlations between microbial abundances and phenotypic traits.
  • Research domains: Application to studies in personalized medicine, nutrition, and disease pathogenesis involving microbiome–host trait associations.

Methodology:

Computational methods map, analyze, and interpret relationships between microbiota composition and host phenotypes and perform direct correlation analysis instead of primarily conducting taxonomic profiling or comparative group analysis.

Topics

Details

License:
MIT
Tool Type:
command-line tool, web application
Programming Languages:
Java
Added:
1/18/2021
Last Updated:
2/19/2021

Operations

Publications

Chen Y, Park J, Natsume-Kitatani Y, Kawashima H, Mohsen A, Hosomi K, Tanisawa K, Ohno H, Konishi K, Murakami H, Miyachi M, Kunisawa J, Mizuguchi K. MANTA, an integrative database and analysis platform that relates microbiome and phenotypic data. PLOS ONE. 2020;15(12):e0243609. doi:10.1371/journal.pone.0243609. PMID:33275647. PMCID:PMC7717536.

PMID: 33275647
PMCID: PMC7717536
Funding: - Japan Society for the Promotion of Science: 17K07268, 17K09604, 18H02150, 18H02674, 18K17997 - Japan Agency for Medical Research and Development: 17ak0101068h0001, 17ek0210078h0002, 17ek0410032s0102, 17fk0108207h0002, 17fk0108223h0002, 17gm1010006s0101, 18ck0106243h0003 - Ministry of Health, Labour and Welfare: 15654110

Links