mapbayr

The `mapbayr` package is a tool for use within the R programming environment. It aims to enhance the model-informed precision dosing (MIPD) approach by offering a means to perform maximum a posteriori Bayesian estimation (MAP-BE) of pharmacokinetic (PK) parameters. This package operates with any population PK model formulated in `mrgsolve`, a feature that underscores its versatility and applicability across a broad range of pharmacokinetic studies.

In addition to its core estimation capabilities, `mapbayr` also offers functionalities for data formatting and reporting and the development of standalone Shiny web applications for MIPD purposes. These features make it a comprehensive tool that does not require additional software beyond R, facilitating broader access to advanced PK parameter estimation techniques within the research and clinical community. Overall, `mapbayr` emerges as a robust and reliable solution for MAP-BE of PK parameters in R, capable of matching or surpassing existing tools like NONMEM under certain conditions.

Topic

Drug metabolism;Metabolomics;Small molecules;Statistics and probability

Detail

  • Operation: Protein structure validation;Standardisation and normalisation

  • Software interface: Library

  • Language: R, C++

  • License: The GNU General Public License v3.0

  • Cost: Free with restrictions

  • Version name: -

  • Credit: -

  • Input: -

  • Output: -

  • Contact: chatelut.etienne@iuct-oncopole.fr

  • Collection: -

  • Maturity: -

Publications

  • Easy and reliable maximum a posteriori Bayesian estimation of pharmacokinetic parameters with the open-source R package mapbayr.
  • Le Louedec F, et al. Easy and reliable maximum a posteriori Bayesian estimation of pharmacokinetic parameters with the open-source R package mapbayr. Easy and reliable maximum a posteriori Bayesian estimation of pharmacokinetic parameters with the open-source R package mapbayr. 2021; 10:1208-1220. doi: 10.1002/psp4.12689
  • https://doi.org/10.1002/PSP4.12689
  • PMID: 34342170
  • PMC: PMC8520754

Download and documentation


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