Mapiya

Mapiya generates intramolecular and intermolecular contact maps and characterizes physicochemical interactions to analyze spatial relationships in proteins, nucleic acids, and their complexes.

Key Features:

• Generation of Contact Maps: Generates intramolecular and intermolecular contact maps for proteins, nucleic acids, and their complexes.
• Characterization of Interactions: Characterizes the physicochemical nature of contacts to describe interaction types within biomolecules.
• Interactive Visualization: Utilizes Molstar for interactive 3D visualization, including automatic zooming on selected contacts.
• Integrated Analyses: Performs sequence- and structure-based analyses using a combination of third-party software and in-house proprietary algorithms.

Scientific Applications:

• Interaction analysis: Investigate protein-protein, protein-nucleic acid, and nucleic acid-nucleic acid interactions.
• Conformational dynamics: Explore conformational changes and dynamics within biomolecular complexes.
• Drug design support: Support drug design by identifying potential interaction sites on target molecules.

Methodology:

Integration of third-party software with in-house proprietary algorithms to generate contact maps and perform sequence- and structure-based analyses, with interactive visualization powered by Molstar.