MASH Explorer

MASH Explorer provides processing and analysis of top-down mass spectrometry proteomics data to enable proteoform-level characterization and proteome-wide molecular specificity studies.

Key Features:

• Universal platform: Integrates multiple spectral deconvolution and database search algorithms into a single environment for top-down proteomics.
• Comprehensive data processing: Supports mass spectrometry data in multiple vendor file formats for processing within the same platform.
• Algorithm integration: Combines spectral deconvolution and database search outputs to enable proteoform-level identification and molecular specificity analysis.

Scientific Applications:

• Proteoform characterization: Identification and characterization of intact proteoforms derived from top-down mass spectrometry data.
• Post-translational modification mapping: Detection and analysis of post-translational modifications at the proteoform level.
• Proteome-wide molecular studies: Proteome-scale investigations of protein function and molecular specificity using top-down proteomics data.

Methodology:

Integration of multiple spectral deconvolution and database search algorithms applied to top-down mass spectrometry data in multiple vendor file formats.