MatchMiner

MatchMiner matches genomically profiled cancer patients to precision medicine clinical trials by comparing tumor genomic alterations against curated trial eligibility criteria.

Key Features:

• Computational Matching: Employs computational matching algorithms to align patient genomic profiles with trial eligibility based on specific genomic alterations.
• Facilitation of Trial Enrollment: Identifies suitable trials for individual patients and provides candidate lists to trial teams to accelerate enrollment.
• Comprehensive Database: Curated a database from March 2016 to March 2021 of 354 precision medicine (PM) trials encompassing genomic and clinical eligibility criteria.
• Impact on Trial Consent Timing: Facilitated 166 MatchMiner consents (MMC) for 159 patients, with consents occurring on average 55 days (22%) earlier than non-MMC consents.

Scientific Applications:

• Precision Medicine Advancement: Enables targeted enrollment of patients into PM trials based on tumor-specific genomic alterations.
• Clinical Trial Efficiency: Reduces time to match patients with suitable trials, expediting trial enrollment and research.

Methodology:

Integrates patient genomic data with a curated PM trial database and applies matching algorithms to align patient profiles with trial eligibility criteria.