MBRole

MBRole performs functional enrichment analysis of chemical compound lists from metabolomics experiments to interpret metabolites' biological roles and associated pathways.

Key Features:

• Functional enrichment analysis: Performs enrichment analysis on lists of chemical compounds obtained from metabolomics experiments to relate metabolites to biological terms and pathways.
• Expanded database integration: MBROLE2 incorporates 10 additional databases and broader vocabularies, including metabolite-protein and drug-protein interaction annotations.
• Automatic identifier conversion: Automatically converts compound identifiers from multiple databases to enable integrated analysis across resources.

Scientific Applications:

• Metabolomics interpretation: Interprets compound lists from metabolomics studies to elucidate the biological roles of specific metabolites.
• Pathway and interaction analysis: Links metabolites to biological pathways and to metabolite-protein and drug-protein interactions for mechanistic insight.
• Systems biology, pharmacology, and personalized medicine: Supports analyses relevant to systems biology, pharmacology, and personalized medicine by providing functional context for metabolites.

Methodology:

Performs functional enrichment analysis on input compound lists and converts compound identifiers using integrated databases (including the 10 additional databases in MBROLE2).