Memoir

Memoir performs template-based homology modeling of membrane proteins to generate structural models that account for lipid bilayer constraints for use in structural biology and drug discovery.

Key Features:

• Specialized homology modeling: Performs template-based structure prediction specifically tailored for transmembrane proteins.
• Alignment and coordinate generation software: Uses alignment and coordinate generation algorithms that consider the unique constraints imposed by the lipid bilayer on protein structure.
• Support for α-helical and β-barrel proteins: Accommodates modeling of both α-helical and β-barrel membrane protein classes.
• Model refinement support: Provides alternative conformations for modeled loops and a multiple sequence alignment integrating the query and template sequences to support refinement.

Scientific Applications:

• Structural biology: Generates membrane protein models to support structural interpretation and functional inference.
• Drug discovery: Provides structural models of membrane protein targets to aid therapeutic design.
• Disease mechanism studies: Enables modeling of membrane proteins to investigate disease-related structural changes.

Methodology:

Template-based homology modeling using alignment and coordinate generation software that accounts for lipid bilayer constraints, producing multiple sequence alignments integrating query and template sequences and alternative loop conformations.