MetaGeneBank

MetaGeneBank aggregates and standardizes deep-sequenced metagenomic data from human fecal specimens to support comparative microbiome analyses and downstream studies in disease research and precision medicine.

Key Features:

• Standardized Database: Stores and processes raw sequencing files from human fecal metagenomes with unified formats and metadata to enable cross-study comparability.
• Comprehensive Data Collection: Contains 4,470 raw sequencing files totaling over 12 terabytes from 16 distinct studies covering more than ten disease types and samples from 14 countries.
• Unified Data-Processing Pipeline: Processes all data using a standardized pipeline to minimize variations introduced during data generation and processing.
• Metadata and Gene Abundances: Includes detailed sample collection information, sequencing methodology metadata, and gene abundance data.
• Search and Query Tools: Provides computational tools for searching by descriptive attributes, gene sequences, microbiota taxonomic profiles, and molecular functions.

Scientific Applications:

• Disease Research: Supports investigation of the role of gut microbiota in diverse diseases using integrated sample, sequencing, and gene abundance data.
• Precision Medicine: Enables analyses that link microbial compositions and molecular functions to health conditions for precision medicine research.
• Comparative and Meta-analysis: Facilitates cross-cohort comparisons and meta-analyses, including assessment of the impact of specimen source relative to sequencing centers or platforms on microbiota variation.

Methodology:

Stores 4,470 raw sequencing files and processes all data using a standardized pipeline; supports computational search by descriptive attributes, gene sequences, microbiota profiles, and functions.