MetaImprint

MetaImprint catalogs mammalian imprinted genes and associated genome-wide genetic and epigenetic data to support analyses of genomic imprinting across eight mammalian species.

Key Features:

• Extensive Gene Collection: Contains 539 imprinted genes from eight mammalian species, including 255 experimentally validated genes.
• Genetic and Epigenetic Data Integration: Aggregates imprinting control regions, single nucleotide polymorphisms (SNPs), non-coding RNAs, DNA methylation patterns, and histone modifications.
• Disease Association and Functional Annotation: Links imprinted genes to human disease associations and provides functional annotations.
• Search Capabilities: Supports queries by gene ID and by disease name.
• Imprinted Gene Browser: Visualizes imprinted genes in a genomic context for spatial examination of loci.
• Epigenetic Changes Analysis Tool: Analyzes DNA methylation and histone modification differences across tissues and cell types.

Scientific Applications:

• Regulatory mechanism analysis: Enables study of genetic and epigenetic regulatory mechanisms underlying genomic imprinting in mammalian development.
• Disease association studies: Facilitates investigation of contributions of imprinted genes to human diseases via curated association data.
• Comparative and discovery research: Supports identification of novel imprinted genes and comparative epigenetic analyses across tissues and species.

Methodology:

Integrates experimentally confirmed data and computational predictions; compiles genome-wide genetic and epigenetic information (imprinting control regions, SNPs, non-coding RNAs, DNA methylation, histone modifications); implements search by gene ID or disease name; provides a genomic browser and an analysis module for DNA methylation and histone modification differences across tissues and cell types.