MetamORF

MetamORF catalogs unique short open reading frames (sORFs) identified by experimental and computational approaches in the human and mouse genomes to provide a normalized, non-redundant resource for sORF annotation and analysis.

Key Features:

• Scope: Catalogs unique sORFs identified by experimental and computational methodologies in human and mouse genomes.
• Data integration: Aggregates publicly available sORF datasets into a single repository.
• Normalization and redundancy removal: Normalizes nomenclature, reprocesses data, and summarizes redundant entries.
• sORF count: Contains 1,162,675 distinct sORFs.
• Annotation levels: Supports analyses at loci, gene, transcript, and ORF levels.
• Nomenclature standardization: Applies a normalized nomenclature to address categories such as short, upstream, and downstream ORFs.
• Genome browser integration: Provides database content via track hubs for the UCSC Genome Browser.

Scientific Applications:

• sORF annotation: Provide standardized annotations of sORFs in human and mouse genomes.
• Comparative analyses: Enable cross-species and conservation studies of sORFs.
• Functional genomics: Support investigation of sORF roles at loci, gene, transcript, and ORF scales.
• Genomic context analyses: Integrate sORF annotations with genomic coordinates via UCSC Genome Browser track hubs.

Methodology:

Integrates publicly available datasets, normalizes nomenclature, reprocesses data to summarize redundant entries, and exports content as UCSC Genome Browser track hubs.