MetaPhors

MetaPhOrs predicts orthology and paralogy relationships among genes across diverse species by synthesizing phylogenetic trees from multiple public repositories to produce genomic-scale evolutionary inferences.

Key Features:

• Extensive Database: Houses over 117 million unique homologs inferred from approximately 8.2 million Maximum Likelihood phylogenetic trees across roughly 4,000 species.
• Integration of Multiple Sources: Aggregates data from 13 different source repositories, combining independent phylogenetic information to enhance prediction breadth.
• Consistency Score and Evidence Level: Assigns a Consistency Score and an Evidence Level for each prediction, reflecting confidence based on the number of supporting trees and their consistency across sources.

Scientific Applications:

• Comparative Genomics: Enables comparative genomic analyses by providing predictions of gene relationships to explore evolutionary histories and functional genomics.
• Functional Annotation: Aids functional annotation by using orthologous and paralogous relationships to predict functions of uncharacterized genes from known homologs.

Methodology:

MetaPhOrs employs a phylogeny-based predictive algorithm that synthesizes information from multiple independent phylogenetic trees, including approximately 8.2 million Maximum Likelihood trees, and aligns predictions with the original definitions of orthology and paralogy.