MetaQuery

MetaQuery quantifies the abundance of specific genes across 1267 publicly available human fecal metagenomes from American, European, and Chinese populations to enable comparative analysis of gene variation with taxonomic and clinical variables.

Key Features:

• Gene Abundance Estimation: Accepts one or more query genes and estimates their abundance across 1267 publicly available fecal metagenomes from American, European, and Chinese populations.
• Gene Co-variation: Identifies correlations in presence or abundance among query genes and other genes.
• Taxonomic Associations: Explores relationships between gene abundance and microbial taxa.
• Clinical Correlations: Tests associations between gene variation and clinical variables such as inflammatory bowel disease and diabetes.
• Genome Size Analysis: Examines associations between gene abundance and average genome size.

Scientific Applications:

• Gene-centric comparative analysis: Enables comparison of specific gene abundance across diverse human gut metagenomes.
• Linking genes to clinical phenotypes: Supports analysis of associations between gene variation and diseases such as inflammatory bowel disease and diabetes.
• Pathway and biomarker investigation: Facilitates study of microbial pathways associated with disease and identification of potential biomarkers or therapeutic targets.

Methodology:

Analyzes 1267 publicly available fecal metagenomes and applies downstream statistical analyses to estimate gene abundances and associations with taxa, clinical variables, gene co-variation, and average genome size.