MetaVR

MetaVR catalogs and expands uncultivated virus genome diversity through a comprehensive database integrating genomic and metagenomic datasets with taxonomic classification, host prediction, and programmatic access capabilities.

Key Features:

• Expanded UViG Collection: MetaVR comprises 24,435,662 uncultivated virus genomes (UViGs), representing a 57.6% increase from IMG/VR-4.0, organized into over 12 million viral operational taxonomic units.
• Taxonomic Framework: MetaVR implements an updated taxonomic framework based on ICTV release 39 and assignment to Baltimore classes.
• Host Information Integration: MetaVR integrates curated eukaryotic host information and enhanced host assignment through the computational tool iPHoP.
• Protein Analysis Resources: MetaVR integrates protein clusters and predicted structures for comparative studies.
• Programmatic Access: MetaVR provides an API for programmatic data access to enable large-scale querying.

Scientific Applications:

• Viral Diversity Exploration: MetaVR enables exploration of viral diversity across diverse environments through its expanded collection of UViGs.
• Viral Evolution Studies: MetaVR supports comparative studies of viral evolution through integrated protein clusters and predicted structures.
• Host-Virus Interaction Analysis: MetaVR facilitates investigation of viral host interactions through curated eukaryotic host information and computational host prediction.

Methodology:

MetaVR is built on the IMG data warehouse and analysis tools. Host assignment employs the computational tool iPHoP. Taxonomic classification follows ICTV release 39 with Baltimore class assignment.