MethBank

MethBank archives 1449 single-base resolution DNA methylomes across 23 species to support comparative and functional epigenomic analyses.

Key Features:

• Data content: MethBank 4.0 contains 1449 single-base resolution methylomes from 23 species covering 236 tissues and cell lines across 15 biological contexts.
• Quality Evaluation: The database applies rigorous quality assessments to methylation datasets to ensure data reliability.
• Standardized Metadata: Metadata are recorded in standardized formats to facilitate integration and comparison across studies.
• Comprehensive Annotations: Detailed annotations are provided for downstream analyses of methylation data.
• Curated Knowledge Modules: Expert-curated modules highlight differentially methylated genes associated with specific biological contexts.
• Methylation Analysis Tools: Integrated tools enable in-depth computational analyses of DNA methylation profiles.

Scientific Applications:

• Comparative epigenomics: Cross-species comparison of single-base resolution DNA methylation patterns.
• Epigenetic regulation studies: Investigation of DNA methylation roles in development, aging, and disease processes.
• Differential methylation analysis: Identification and interpretation of differentially methylated genes linked to biological contexts.

Methodology:

MethBank 4.0 implements dataset quality evaluation, metadata standardization, comprehensive annotation, expert curation of knowledge modules, and incorporates computational tools for DNA methylation analysis.