DNA Methylation Database

DNA Methylation Database (MethDB) aggregates DNA methylation data for 5-methylcytosine (5mC) to support analysis of epigenetic regulation of gene expression across organisms.

Key Features:

• Data Integration: Integrates DNA methylation measurements at multiple resolutions, from overall 5mC content in total DNA to single-nucleotide methylation status.
• Detailed Metadata Storage: Records metadata including sample origin and specifics of experimental procedures for each dataset.
• Advanced Query Capabilities: Enables filtered queries using query masks by 5mC content, species, tissue type, gene, sex, phenotype, sequence ID, and DNA type.
• Comprehensive Data Presentation: Provides methylation profiles and relative gene expression as graphical and tabular outputs, including sequences annotated with 5mC and tables of sequence positions with corresponding methylation levels.

Scientific Applications:

• Epigenetic regulation of gene expression: Facilitates analysis of correlations between 5mC distribution and gene expression levels.
• Development and environmental response: Supports studies of methylation changes during cellular development and in response to environmental factors.
• Disease research and oncogenesis: Enables investigation of methylation alterations in disease states such as cancer, including roles in gene silencing and oncogenesis.
• Heritability and dynamics: Allows examination of heritable and dynamic changes in 5mC distribution across samples and conditions.

Methodology:

Data are derived from diverse experimental techniques that measure DNA methylation at varying resolutions and are provided as raw data and processed results.