MethylomeDB

MethylomeDB provides genome-wide, single-CpG resolution DNA methylation profiles of human and mouse brain tissue for research on epigenetic mechanisms in brain development and neuropsychiatric disorders.

Key Features:

• Genome-wide single-CpG resolution: MethylomeDB contains methylation measurements at single-CpG resolution across the genome.
• High-resolution methylation profiles: The database includes high-resolution methylation profiles derived from diverse brain samples.
• Sample diversity: Datasets include non-psychiatric controls, schizophrenia patients, and individuals with depression.
• Cross-species forebrain data: Contains methylation data from both human and mouse forebrain specimens to enable comparative analyses.
• Integration of published datasets: Proprietary data are integrated with published DNA methylation datasets from other research groups.
• Data formats: Methylation data are provided in wiggle and microarray file formats.

Scientific Applications:

• Epigenetics of neuropsychiatric disorders: Enables analysis of DNA methylation patterns associated with schizophrenia and depression.
• Neurodevelopmental studies: Supports investigation of methylation changes relevant to brain development and function.
• Comparative epigenomics: Facilitates cross-species comparisons to identify conserved methylation patterns between human and mouse forebrain.
• Disease-associated locus identification: Allows interrogation of specific CpG sites to detect methylation changes linked to disease states.

Methodology:

Genome-wide methylation profiles are provided at single-CpG resolution and integrated from proprietary and published datasets, with outputs represented in wiggle and microarray formats.