MEXPRESS

MEXPRESS visualizes TCGA gene-level expression, DNA methylation, and clinical data to enable interpretation of relationships between methylation, expression, and clinical variables.

Key Features:

• Single-Gene Level Analysis: Provides detailed per-gene displays of expression levels, DNA methylation probes, and associated clinical variables within TCGA datasets.
• Integrated Visualization: Combines expression, DNA methylation, and clinical data into a cohesive visualization to examine co-occurrence and patterns at the single-gene level.
• Methylation–Expression Association: Enables visualization of associations between DNA methylation and gene expression across TCGA samples.

Scientific Applications:

• Biomarker Investigation: Investigate candidate biomarkers and genes of interest within TCGA datasets by linking molecular and clinical data.
• GSTP1 in Prostate Adenocarcinoma: Visualize and interpret GSTP1 expression and methylation data in prostate adenocarcinoma from TCGA.
• MLPH and PAM50 Breast Cancer Subtypes: Analyze DNA methylation differences of the PAM50 marker gene MLPH across breast cancer subtypes and link these differences to gene expression.

Methodology:

Aggregates TCGA expression, DNA methylation, and clinical data for single-gene visualization and inspection of methylation–expression and clinical associations.