MG-ncRexplorer

MG-ncRexplorer analyzes non-coding RNA interactions (miRNA, lncRNA, circRNA) with brain microglia by integrating manually curated and computationally detected associations and GEO expression profiles to support regulatory network construction and identification of risk-associated miRNAs in glioma.

Key Features:

• Systematic Association Construction: Constructs ncRNA–microglia associations via manual retrieval from published studies and computational detection, including 648 experimentally verified ncRNA-microglia interactions.
• Expression Profile Integration: Integrates expression profiles extracted from GEO, including 9 miRNA and 1 lncRNA profiles and 31 sample-match miRNA and mRNA expression profiles covering 2335 normal or disordered brain samples.
• Regulatory Network Construction: Builds regulatory target networks based on manually retrieved associations to represent interactions between ncRNAs and microglia.
• Risk Factor Identification: Identifies risk-associated miRNAs in conditions such as glioma by analyzing multiple high-throughput expression profiles.

Scientific Applications:

• Elucidating Regulatory Mechanisms: Maps ncRNA–microglia interactions to reveal regulatory relationships that modulate microglial responses.
• Disease Biomarker Discovery: Enables identification of miRNA candidates associated with glioma and other brain disorders for biomarker investigation.
• Therapeutic Target Identification: Supports discovery of ncRNA-mediated targets for modulating microglial activity in neuroinflammatory and neurodegenerative contexts.

Methodology:

Manual retrieval from published studies and computational detection to construct ncRNA–microglia associations; integration of GEO expression profiles (9 miRNA, 1 lncRNA, and 31 sample-match miRNA/mRNA profiles covering 2335 samples); construction of regulatory target networks from manually retrieved associations; identification of risk-associated miRNAs using multiple high-throughput expression profiles.