MGV

MGV visualizes and compares chromosomal regions and annotated genomic features across multiple assembled genomes, including 16 inbred mouse strains and two wild-derived strains, to support comparative genomics and mouse genetics studies.

Key Features:

• Comparative Visualization: Displays chromosomal regions from multiple genomes as horizontal tracks for simultaneous visual comparison.
• Highlighting Equivalent Features: Employs vertical "swim lane" connectors to link equivalent features across genome tracks.
• Synchronized Navigation: Maintains alignment of genomic coordinates across tracks through synchronized scroll and zoom.
• Customizable Feature Sets: Generates custom sets of genes and other genome features based on criteria including genome coordinates, function, phenotype, disease associations, or pathway terms.

Scientific Applications:

• Mouse genetics: Enables exploration and comparison of genome annotations among inbred and wild-derived mouse strains to investigate genetic variation and strain-specific features.
• Phenotype and disease association analysis: Supports association of genes and genomic regions with phenotype and disease terms using displayed annotations and selected feature sets.
• Comparative genomics and homology analysis: Facilitates identification of conserved elements and homologous features across genomes using linked feature visualization.
• Evolutionary studies: Assists comparative analyses relevant to evolutionary investigations by enabling genome-agnostic display of homologous features across organisms.

Methodology:

MGV displays chromosomal regions as horizontal tracks linked by vertical "swim lane" connectors, maintains synchronized scroll and zoom across tracks, allows generation of custom feature sets via criteria (genome coordinates, function, phenotype, disease associations, pathway terms), and is genome-agnostic to display homologous features across genomes.