MHC Motif Atlas

MHC Motif Atlas catalogs binding specificities and curated ligand datasets for Major Histocompatibility Complex (MHC) molecules to support analysis of MHC–peptide binding and T-cell epitope presentation.

Key Features:

• Coverage: Comprehensive data on thousands of class I and class II MHC molecules.
• Binding motifs: Detailed binding motifs characterizing MHC–peptide interactions.
• Peptide length distributions: Empirical peptide length distributions across MHC ligands.
• Phosphorylated ligands: Motifs and annotations associated with phosphorylated ligands.
• Multiple specificities: Annotations of multiple specificities observed for certain MHC alleles.
• Structural integration: Links to X-ray crystallography structures to relate motifs to atomic-level interactions.
• Curated ligand datasets: Curated collections of MHC ligands comprising over a million entries.

Scientific Applications:

• T-cell epitope analysis: Mapping how pathogen- or cancer-derived peptides bind and are presented by MHC molecules for T-cell recognition.
• Vaccine design: Informing selection of candidate peptides for personalized cancer vaccine development.
• Adoptive cell therapy: Supporting identification of target peptides for adoptive T-cell therapy development.
• Structure–function studies: Correlating peptide-binding motifs with X-ray crystallography data to study atomic-level MHC–peptide interactions.

Methodology:

The provided description does not specify computational methods, algorithms, or processing pipelines used.