miR2Diabetes

miR2Diabetes catalogues literature-curated microRNA (miRNA) expression patterns associated with diabetes mellitus (DM) and its microvascular complications (DMCs) to link miRNA dysregulation with specific diabetic phenotypes.

Key Features:

• Comprehensive Coverage: Contains annotations across 14 distinct DM and DMC phenotypes covering 156 miRNAs.
• Diverse Sample Origins: Includes annotations derived from blood, kidney, liver, and other tissues.
• Disease Model Organism Annotations: Incorporates miRNA annotations from disease-model organisms such as rats and mice.
• Manual Curation: Annotations are manually curated to capture phenotype-specific miRNA dysregulation patterns.
• Literature-Backed Entries: Each entry is supported by literature references linking miRNAs to DM and DMC observations.

Scientific Applications:

• Biomarker Discovery: Facilitates identification of candidate miRNA biomarkers for early diagnosis or monitoring of disease progression in DM and DMCs.
• Functional Validation Prioritization: Enables prioritization of miRNAs for experimental validation of roles in diabetes pathogenesis and complications.
• Cross-Disease Insights: Supports comparative analyses to explore shared miRNA dysregulation patterns between DM/DMCs and other diseases.

Methodology:

Manual literature curation of miRNA–diabetes associations with annotation of phenotype, sample origin, species, and literature references.