MIAOME

MIAOME catalogs interactions between human microbiota and host epigenetic regulation, focusing on microbiota-derived metabolites (MDM), microbiota-derived components (MDC), and microbiota-secreted proteins (MSP) that modulate histone modifications, DNA modifications, and non-coding RNAs.

Key Features:

• Data composition: Compiles 1,068 human microbes (63 genera, 281 species, 707 strains), 91 unique microbiota-derived metabolites/components (e.g., fatty acids, bile acids, vitamins), 50 microbes secreting 40 distinct proteins, and 98 microbes directly involved in host epigenetic modification.
• Microbial influence categories: Distinguishes three classes of microbial factors—MDM, MDC, and MSP—that affect host gene expression via epigenetic mechanisms.
• Epigenome classification: Categorizes the epigenome into four types of DNA modifications, twenty histone modifications, and regulations involving 490 non-coding RNAs.
• Disease associations: Links microbial-epigenetic entries to 160 human diseases.
• Integration of factors: Integrates microbial metabolites, components, and secreted proteins with corresponding host epigenetic modifications to enable analysis of their interactions.
• Data sources: Assembles information from literature reviews and biochemical databases.

Scientific Applications:

• Microbiome–epigenome relationship analysis: Enables study of how microbial metabolites, components, and proteins modulate host epigenetic mechanisms in human health and disease.
• Disease mechanism and target identification: Provides links between microbial-epigenetic changes and 160 human diseases to support investigation of disease mechanisms and potential therapeutic targets.
• Interaction mapping: Supports analysis of interactions among metabolites, components, secreted proteins, and host epigenetic modifications.

Methodology:

Data were compiled from literature reviews and biochemical databases, and epigenetic entries were categorized into DNA modifications, histone modifications, and non-coding RNA regulations.