MICHA

MICHA standardizes the annotation and reporting of chemosensitivity assays to enable FAIRification (Findable, Accessible, Interoperable, Reusable) of drug sensitivity screening experiments.

Key Features:

• Automated data extraction: Automates extraction of publicly available information required for comprehensive assay annotation.
• Annotation scope: Supports annotation of compounds, samples, reagents, and data processing methods.
• Compound annotations: Provides detailed compound annotations including chemical structures, targets, and disease indications via an integrated database.
• Standardization: Standardizes assay information to reduce inconsistencies in experimental materials and protocols.
• Curated catalogues: Annotates cell line samples, assay protocols, and literature references using manually curated catalogues.
• FAIR report generation: Generates reports adhering to FAIR (Findable, Accessible, Interoperable, Reusable) principles for drug screening studies.

Scientific Applications:

• Preclinical drug discovery and clinical-trial optimization: Standardizes chemosensitivity assay metadata to improve reproducibility and comparability across studies.
• FAIRification of published studies: Produced FAIRified protocols from five major cancer drug screening studies and six recent COVID-19 studies.
• Data integration for drug sensitivity analyses: Enables aggregation of compound, target, and disease indication data to support integrative analyses of drug screening experiments.

Methodology:

Automated extraction of publicly available information for assay annotation; integration into a web server and database providing compound annotations; use of manually curated catalogues to annotate cell line samples, assay protocols, and literature references; generation of reports adhering to FAIR principles.