Microbe Browser

Microbe Browser aggregates and integrates microbial genomic and functional annotation data from public databases to support comparative analysis of bacterial and archaeal genomes.

Key Features:

• Data integration: Aggregates and cross-references entries from GenBank, RefSeq, UniProt, InterPro, Gene Ontology, and the Orthologs Matrix Project (OMA).
• Daily updates: Synchronizes content with source databases on a daily basis to maintain current genomic data.
• Genome coverage: Includes all completely sequenced bacterial and archaeal genomes.
• Gene predictions: Provides gene predictions derived from five different gene prediction software packages.
• Functional annotation: Includes functional annotations and domain information from UniProt, InterPro, and Gene Ontology.
• Orthology data: Incorporates orthology information from the Orthologs Matrix Project (OMA).
• Programmatic access: Exposes data programmatically through an API provided via the OMA project.

Scientific Applications:

• Comparative genomics: Enables comparative analyses across bacterial and archaeal genomes using integrated sequence and annotation data.
• Gene annotation validation: Facilitates cross-verification of gene annotations by comparing outputs from multiple gene prediction packages and reference databases.
• Orthology and evolutionary analyses: Supports orthology-based and evolutionary studies using OMA-derived ortholog information.
• Large-scale automated workflows: Supports incorporation into large-scale genomic studies and automated pipelines via the OMA API.

Methodology:

Aggregates data from GenBank, RefSeq, UniProt, InterPro, Gene Ontology, and OMA; performs daily updates; includes gene predictions from five software packages; and provides programmatic access via the OMA API.