MIKB

MIKB consolidates and integrates curated multi-omics, genetic, and risk-factor data on myocardial infarction to support translational and molecular research.

Key Features:

• Literature-derived repository: Contains data extracted from 4,817 research articles yielding 9,701 records that include 2,054 single factors, 209 combined factors, 243 risk models, 37 MI subtypes, and 3,406 interactions between single factors and MI conditions.
• MIGD (Myocardial Infarction Genomic Database) module: Includes 1,782 omics factors, 28 MI subtypes, 2,347 interactions between omics factors and MI conditions, 1,253 genes, and six chromosomal alterations sourced from 2,647 research articles.
• Multi-omics integration: Integrates genomic, multi-omics factors and their functional annotations to link molecular data with MI phenotypes.
• Risk models and factors: Catalogues 243 risk models and both single and combined risk factors for use in risk assessment and diagnostic prediction studies.
• Gene function and drug interaction annotations: Documents functions of MI-related genes and their interactions with pharmaceuticals to enable investigation of gene–drug relationships.

Scientific Applications:

• Risk assessment: Use the curated single factors, combined factors, and 243 risk models to support myocardial infarction risk evaluation.
• Diagnostic prediction: Employ the repository of factors and interactions to develop or validate diagnostic prediction models for MI.
• Molecular pathogenesis studies: Leverage MIGD multi-omics data and functional annotations to investigate molecular mechanisms of MI.
• Precision medicine and pharmacogenomics: Analyze documented gene functions and gene–pharmaceutical interactions to support precision cardiovascular therapies.
• Translational research on MI heterogeneity: Integrate multi-omics, genetic, and risk-factor data to study MI subtypes and personalized treatment strategies.

Methodology:

Data were generated by literature curation and integration of findings from research articles into structured records and functional annotations.