miR-TV

miR-TV visualizes and integrates 5p- and 3p-arm miRNA expression with mRNA target expression to analyze miRNA–target relationships and their clinical associations in human cancer.

Key Features:

• Integration of Expression Profiles: Incorporates 5p-arm and 3p-arm miRNA expression profiles alongside mRNA target gene expression from healthy and cancerous populations.
• Clinical Data Correlation: Links expression data with clinical metadata including patient survival information sourced from The Cancer Genome Atlas (TCGA).
• Predictive Target Gene Analysis: Utilizes miRNA target predictions from miRDB, targetScan, and miRanda to identify potential miRNA–target interactions.
• Interactive Data Visualization: Generates interactive visualizations using the D3 JavaScript toolkit to represent miRNA and target gene relationships.

Scientific Applications:

• Gene Expression Regulation Studies: Enables comparison of miRNA regulatory patterns between normal and cancerous tissues to study gene expression regulation.
• Survival Analysis: Facilitates correlation of miRNA and target gene expression with patient survival to identify potential prognostic markers.
• Functional Genomics Research: Supports investigation of functional implications of predicted miRNA–target interactions in cellular processes.

Methodology:

miRNA-seq and mRNA-seq data from TCGA were integrated with clinical datasets; miRDB, targetScan, and miRanda were used for miRNA–target prediction; D3 JavaScript toolkit was used to generate interactive visualizations.