MiREDiBase

MiREDiBase catalogs validated and putative microRNA (miRNA) editing events, focusing on Adenosine-to-Inosine (A-to-I) and Cytosine-to-Uracil (C-to-U) modifications to support analysis of miRNA editing effects on biogenesis and target regulation.

Key Features:

• Curated Catalog: Includes 3,059 unique validated and putative editing sites across 626 pre-miRNAs in humans and three primates, compiled through manual curation.
• Functional Predictions: Provides miRNA-target predictions and enrichment analysis for editing events identified in mature human miRNAs.
• Structural Insights: Supplies inferred minimum free energy (MFE) structures for edited pre-miRNAs to assess potential effects on miRNA folding and processing.
• Dedicated Scope: Focuses specifically on miRNA editing, distinguishing its content from broader RNA editing resources.

Scientific Applications:

• Functional impact analysis: Enables investigation of how A-to-I and C-to-U editing alters miRNA target recognition and regulatory networks via target predictions and enrichment analysis.
• Biogenesis and structural studies: Supports analysis of editing effects on miRNA precursor structure and potential consequences for miRNA maturation using MFE structures.
• Disease and developmental research: Facilitates studies that link miRNA editing events to molecular mechanisms in disease and developmental biology.

Methodology:

Manual curation of validated and putative editing sites from literature and datasets; miRNA-target prediction and enrichment analysis for edited mature miRNAs; inference of minimum free energy structures for edited pre-miRNAs.