Mirin

Mirin integrates miRNA regulations, protein–protein interactions (PPIs), and mRNA and miRNA expression profiles to identify perturbed miRNA-mediated regulatory modules and oncomirs in disease contexts such as gastric and breast cancer.

Key Features:

• Integration of Multi-Omics Data: Combines miRNA regulations, protein–protein interactions (PPIs), and mRNA and miRNA expression profiles to analyze regulatory networks.
• Condition Specification: Supports specifying biological conditions, such as cancer types (e.g., gastric and breast cancer), for targeted exploration of miRNA-mediated regulation.
• Identification of Oncomirs: Detects oncomirs (cancer-related miRNAs) and their associated regulatory networks in cancers such as gastric and breast cancer.
• Functional Module Analysis: Constructs and analyzes functional modules within PPI networks to map miRNA-mediated interactions and disrupted regulatory elements.

Scientific Applications:

• Perturbed Regulatory Module Identification: Identifies perturbed miRNA regulatory modules to characterize how aberrant miRNAs influence protein interactions and gene expression in specific pathological contexts.
• Oncomir Discovery and Mechanistic Inference: Enables discovery of oncomirs and their regulatory networks in cancers (e.g., gastric, breast) to inform hypotheses about molecular mechanisms and potential therapeutic targets.

Methodology:

Systematically integrates data on miRNA regulations, PPIs, and mRNA and miRNA expression profiles to construct and analyze functional modules within PPI networks and identify key regulatory elements disrupted in disease states, mapping miRNA-mediated interactions.