MitoCounter

MitoCounter quantifies mitochondrial DNA (mtDNA) copy number from whole genome sequencing (WGS) datasets to enable analysis of mtDNA variation relevant to aging and disease.

Key Features:

• Accurate Assessment: Employs a novel computational method to quantify mitochondrial DNA (mtDNA) copy number from whole genome sequencing (WGS) data.
• WGS Compatibility: Compatible with human whole genome sequencing datasets from the HapMap and 1000 Genomes projects.
• NGS-based Unbiased Estimation: Leverages next-generation sequencing (NGS) capabilities to provide unbiased and cost-effective mtDNA copy number estimates.
• Validation: Validated using human whole genome sequencing datasets from the HapMap and 1000 Genomes projects.

Scientific Applications:

• Aging Biomarker Research: Enables exploration of mtDNA copy number as a biomarker for aging and aging-related diseases, including analysis of generational variation.
• Disease Correlation Studies: Facilitates investigation of correlations between mtDNA copy number and various diseases to support diagnostic and therapeutic research.

Methodology:

Leverages next-generation sequencing (NGS) data and has been validated using human whole genome sequencing datasets from the HapMap and 1000 Genomes projects.