MitopatHs

MitopatHs provides curated logical and graphical representations of biochemical pathways within human mitochondria to support research on energy metabolism, ion homeostasis, and cell death.


Key Features:

  • Comprehensive Pathway Visualization: Presents biochemical pathways as sequences of reactions in a logical view that represents stepwise biochemical deductions.
  • Graphical Visualization: Provides a graphical view that displays and allows analysis of each step within mitochondrial pathways.
  • Manually Curated Content: Contains manually curated pathway entries assembled by experts to ensure accurate and up-to-date information.

Scientific Applications:

  • Energy metabolism: Enables analysis of mitochondrial energy production processes.
  • Ion homeostasis: Supports study of mitochondrial ion regulation mechanisms.
  • Apoptosis and cell death: Facilitates investigation of apoptosis and programmed cell death pathways involving mitochondria.

Methodology:

Integration of various mitochondrial databases to create a unified platform presenting pathway information in both logical and graphical formats.

Topics

Details

License:
GPL-3.0
Tool Type:
web application
Programming Languages:
PHP
Added:
10/10/2021
Last Updated:
10/10/2021

Operations

Publications

Marchi S, Zanella M, Pinton P, Crafa S, Boniolo G. MitopatHs: A new logically-framed tool for visualizing multiple mitochondrial pathways. iScience. 2021;24(4):102324. doi:10.1016/j.isci.2021.102324. PMID:33889820. PMCID:PMC8050385.

PMID: 33889820
PMCID: PMC8050385
Funding: - Fondazione Telethon: 2017 E5L5P3, GGP11139B - Associazione Italiana per la Ricerca sul Cancro: IG-23670 - Ministero della Salute: GR-2016-02364602

Documentation

Links