MloDisDB

MloDisDB curates associations between membrane-less organelles (MLOs), liquid–liquid phase separation (LLPS) components, and diseases to support research on MLO-related pathophysiology.

Key Features:

• Curated Entries: The database contains 771 curated entries derived from 607 publications, each detailing the specific MLO, the associated disease, and implicated functional factors.
• Evidence-Based Classification: Each entry is classified by level of evidence from the original research as Direct Experiment, Indirect Experiment, or Clinical Investigation.
• Functional Insights: Records include associations between MLOs and diseases, documented changes in MLOs, alterations in functional factors, and integrated predictions of components involved in LLPS.
• Comprehensive Coverage: The resource covers MLOs and LLPS-related disease associations with emphasis on MLOs such as nucleoli, nuclear speckles, and stress granules that form through LLPS by condensing proteins and RNAs.

Scientific Applications:

• Pathophysiology Research: Enables study of the roles of MLO dysfunction and LLPS in disease processes.
• Therapeutic Target Identification: Supports investigations into potential therapeutic targets and interventions linked to MLOs and LLPS components.
• Mechanistic Studies and Experimental Design: Provides detailed molecular associations to facilitate hypothesis generation and experimental planning for studies of disease mechanisms.

Methodology:

Entries were compiled through literature review and manual data curation from peer-reviewed publications.