MMMDB

MMMDB provides comprehensive quantitative metabolomic profiles across multiple mouse tissues to enable analysis of tissue-specific and pathway-level metabolite concentration balances.

Key Features:

• Quantitative Data: Provides quantified concentrations of individual metabolites across tissues for comparative analysis.
• Tissue Coverage: Contains metabolomic data from cerebra, cerebella, thymus, spleen, lung, liver, kidney, heart, pancreas, testis, and plasma.
• Analytical Coverage: Derived from non-targeted capillary electrophoresis time-of-flight mass spectrometry analyses identifying 428 unique features and annotating 219 metabolites.
• Comprehensive Annotations: Includes electropherograms and mass spectra with isotope and fragment information linked to metabolite annotations.
• Data Normalization: Supplies normalized quantitative data to support direct comparison of metabolite concentrations across samples.
• Visualization: Provides visualization of overlaid electropherograms to support comparative spectral analysis.

Scientific Applications:

• Cross-study comparison: Enables comparison of metabolomic profiles across experiments while addressing differences in absolute concentration.
• Pathway-level analysis: Facilitates assessment of relative metabolite balances within metabolic pathways.
• Disease modeling: Supports investigation of tissue-specific metabolic alterations relevant to disease states.
• Drug discovery and systems biology: Informs studies of systemic metabolic interactions for drug effects and systems-level analyses.

Methodology:

Non-targeted analyses were performed using capillary electrophoresis time-of-flight mass spectrometry (CE-TOFMS); annotations include electropherograms and mass spectra with isotope and fragment information.