MMRRC

MMRRC maintains and distributes mutant mouse models, preserved as live mice, frozen germplasm, or embryonic stem cells, to support biomedical research, disease modeling, and reproducibility.

Key Features:

• Repository Content: Maintains an archive of mutant mouse models with nearly 60,000 distinct mutant alleles stored as live mice, frozen germplasm, or embryonic stem cells.
• Model Acquisition: Accepts submissions of unique mutant mouse models from academic and commercial entities.
• Genetic Assays: Provides genetic assays to validate and characterize mutant alleles.
• Microbiome Analysis: Performs microbiome analysis on repository mouse colonies and samples.
• Analytical Phenotyping and Pathology: Conducts analytical phenotyping and pathology to assess model phenotypes.
• Cryorecovery Techniques: Uses cryorecovery methods for restoration of frozen germplasm and embryos.
• Mouse Husbandry Guidance: Offers husbandry guidance to support colony maintenance and experimental reproducibility.
• Infectious Disease Surveillance and Diagnosis: Performs infectious disease surveillance and diagnostic testing for repository animals.
• Disease Modeling Services: Supports development and use of mouse models for disease modeling.
• Training and Consultation: Provides experiential training and consultation on the responsible use of mice in research.
• Informatics Coordination (ICSC): Coordinates informatics and repository operations across regional Centers.
• Repository Scale and Distribution: Has fulfilled over 13,184 orders serving 9,591 scientists at 6,626 institutions.

Scientific Applications:

• Disease Modeling: Enables creation and distribution of mouse models to study human diseases and pathophysiology.
• Genetic and Functional Genomics: Supports genetic studies and functional characterization of mutant alleles.
• Microbiome Research: Facilitates studies linking microbiome composition to phenotype in mouse models.
• Infectious Disease Research: Provides animals and diagnostic services for infectious disease investigations.
• Phenotype and Pathology Studies: Enables systematic phenotyping and pathology analyses to link genotype to phenotype.
• Reproducibility and Long-term Preservation: Preserves mouse lines in perpetuity to ensure reproducibility and compliance with NIH policies.

Methodology:

The Informatics Coordination and Service Center (ICSC) coordinates repository operations and informatics across the Consortium Centers.