MNDR

MNDR curates associations between non-coding RNAs (ncRNAs) and diseases, integrating experimentally supported and predicted ncRNA-disease associations to support analysis across mammalian species.

Key Features:

• Extensive Data Coverage: MNDR v3.1 contains over one million ncRNA-disease association entries across more than 1,600 diseases, including 6,301 microRNAs (miRNAs), 39,880 long non-coding RNAs (lncRNAs), 20,256 circular RNAs (circRNAs), 10,894 PIWI-interacting RNAs (piRNAs), and 521 small nucleolar RNAs (snoRNAs).
• Species Coverage: The repository includes data from 11 mammalian species.
• Evidence Types: The database integrates experimentally supported and predicted associations curated from manual literature reviews and other relevant resources.
• Drug Annotations: MNDR v3.1 incorporates ncRNA-disease related drug annotations linking ncRNAs to potential therapeutic contexts.
• Subcellular Localization and Interactions: The resource includes information on ncRNA subcellular localizations and ncRNA interactions relevant to functional interpretation in disease mechanisms.
• Predictive Tools: The repository provides three prediction tools for forecasting miRNA-, lncRNA-, and circRNA-disease associations.

Scientific Applications:

• Disease Mechanism Elucidation: The dataset supports analysis of how ncRNA dysregulation contributes to disease pathogenesis through curated associations and interaction data.
• Drug Discovery and Development: Drug-related annotations enable exploration of ncRNAs as potential therapeutic targets or biomarkers.
• Comparative Genomics and Evolutionary Studies: Multi-species coverage facilitates comparative analyses of ncRNA conservation and divergence in disease contexts across mammals.

Methodology:

Associations are curated from manual literature reviews and other resources and include predicted associations generated by the repository's three prediction tools for miRNA, lncRNA, and circRNA-disease associations.