Mnemiopsis Genome Project Portal

The Mnemiopsis Genome Project Portal provides access to computationally predicted protein structures for the ctenophore Mnemiopsis leidyi, generated using AlphaFold, to facilitate research into early animal evolution and human health.

Key Features:

• Protein Structure Predictions: The portal provides access to 15,333 proteome-scale protein structure predictions generated using AlphaFold for Mnemiopsis leidyi.
• Structure Search: The portal includes publicly available search tools for exploring protein structure predictions.
• Structure Manipulation: The portal includes publicly available manipulation tools for protein structure predictions.
• Structure Visualization: The portal includes publicly available visualization tools for protein structure predictions.
• Structure Comparison: The portal enables comparison of predicted structures to experimentally determined structures, as demonstrated for mnemiopsin 1 and the ionotropic glutamate receptor (iGluR).

Scientific Applications:

• Early Animal Evolution Research: The portal supports the study of early animal evolution by positioning non-bilaterian species such as Mnemiopsis as model systems.
• Human Health Research: The portal facilitates research into human health through access to predicted protein structures.
• Photoprotein Structure Analysis: The portal enables structural analysis of light-sensitive proteins such as mnemiopsin 1.
• Receptor Structure Analysis: The portal enables structural analysis of ionotropic glutamate receptors (iGluR).

Methodology:

Protein structures were predicted using AlphaFold.