MobilityTransformR

MobilityTransformR performs mobility scaling of capillary zone electrophoresis-mass spectrometry (CE-MS) data to standardize migration times across runs and instruments for comparative metabolomics analyses.

Key Features:

• Effective Mobility Scaling: Performs mobility scaling on CE-MS datasets to adjust migration time variations across runs or instruments.
• Integration with R/Bioconductor Ecosystem: Leverages R and Bioconductor functionalities to integrate with MS-based metabolomics workflows.
• Reproducibility: Transforms CE-MS data to support consistent results across studies by standardizing mobility measurements.

Scientific Applications:

• Comparative metabolomics: Standardizes migration times to enable direct comparison of CE-MS datasets across experimental conditions or laboratories.
• Biomarker discovery: Improves reliability of detecting and comparing metabolite signals for biomarker identification in CE-MS studies.
• Metabolic pathway and large-scale omics studies: Reduces mobility-induced variability to support metabolic pathway analysis and large-scale omics investigations.

Methodology:

Adjusts migration times in CE-MS data using mobility-scaling algorithms to account for variability introduced by instrumental or procedural differences.