ModPred

ModPred predicts up to 23 types of post-translational modifications (PTMs) on proteins to identify modification sites and support analysis of PTM crosstalk and protein regulation.

Key Features:

• Unified Sequence-Based Prediction: ModPred employs a unified sequence-based approach to predict sites of multiple PTMs across protein sequences.
• Comprehensive PTM Coverage: The tool predicts 23 distinct types of post-translational modifications (PTMs).
• Crosstalk Analysis: By integrating experimentally determined and predicted PTM sites, ModPred enables investigation of interactions between different PTMs and their combined effects on protein function.

Scientific Applications:

• Characterization of Protein Function Regulation: ModPred aids in understanding how multiple PTMs interact within proteins involved in transcriptional, posttranscriptional, and developmental processes.
• Intrinsically Disordered Regions (IDRs): The tool highlights the role of IDRs in accommodating multiple PTMs and their importance in complex regulatory mechanisms.
• Protein-Protein Interactions: ModPred provides evidence that molecular recognition features (MoRFs) show preferences for PTM sites, particularly shared PTM sites, implicating PTMs in modulation of macromolecular interactions.

Methodology:

ModPred uses sequence-based predictors to identify potential PTM sites across proteins and analyzes both single and shared PTM sites with attention to IDRs and MoRFs.