Molligen

Molligen provides a database and analysis resources for comparative genomics of bacteria in the class Mollicutes, hosting annotated genomes (including Mycoplasma genitalium, Mycoplasma pneumoniae, Ureaplasma urealyticum-parvum, Mycoplasma pulmonis, Mycoplasma penetrans, and Mycoplasma gallisepticum) to enable orthology analysis, sequence-similarity searches, and genome visualization.

Key Features:

• Comprehensive Genomic Data: Contains annotated sequence data for 72 genomes across 51 Mollicutes species.
• Integrated Analysis Tools: Supports searches based on annotation, chromosomal position, and sequence similarity.
• Precomputed Orthology Relationships: Provides precomputed putative ortholog relationships among the included genomes.
• Dynamic Visualization Tools: Includes a graphical multi-genome browser that displays precomputed similarities and genomic features.
• Integration with Public Databases and Tools: Links analyses to external resources including BLAST searches and multiple alignments.
• Continuous Genome Integration: Structured to incorporate new complete mollicute genomes as they become available.

Scientific Applications:

• Pathogenicity Studies: Comparative analyses between pathogenic and non-pathogenic species to identify genetic determinants of virulence.
• Evolutionary Biology: Use of precomputed orthology to investigate evolutionary relationships and divergence among Mollicutes.
• Metabolic Pathway Analysis: Comparison of metabolic capabilities and pathway differences across species.

Methodology:

Uses annotated genome sequences, precomputed orthology relationships, sequence-similarity and positional searches, BLAST and multiple-alignment links, and a multi-genome browser displaying precomputed similarities and genomic features.