Molstar Viewer

Molstar Viewer renders and analyzes large biomolecular structures, including macromolecular assemblies determined by X-ray crystallography and electron microscopy, and supports streaming of molecular dynamics trajectories, cell-level models, and integrative/hybrid (I/HM) models.


Key Features:

  • 3D Visualization: Renders large biomolecular structures and can display up to hundreds of superimposed protein structures simultaneously for comparative analysis.
  • Data Streaming: Streams molecular dynamics simulation trajectories and cell-level models to enable inspection of dynamic processes.
  • Integrative/Hybrid Methods (I/HM) Support: Displays extensive integrative/hybrid method models for assemblies derived from multiple experimental techniques.
  • Annotations: Presents structure quality, functional, and biological context annotations alongside 3D models.

Scientific Applications:

  • Repository Visualization: Employed by PDBe and RCSB PDB for 3D structure visualization of deposited entries.
  • Structural Biology Research: Used for studying macromolecular machines and large assemblies determined by crystallography and electron microscopy.
  • Molecular Interaction and Function Analysis: Enables exploration of complex biological systems to analyze molecular interactions and infer functional mechanisms.

Methodology:

The development combined LiteMol and NGL Viewers and provides high-performance graphics rendering and efficient data management.

Topics

Details

Tool Type:
web application
Added:
10/11/2021
Last Updated:
11/24/2024

Operations

Publications

Sehnal D, Bittrich S, Deshpande M, Svobodová R, Berka K, Bazgier V, Velankar S, Burley SK, Koča J, Rose AS. Mol* Viewer: modern web app for 3D visualization and analysis of large biomolecular structures. Nucleic Acids Research. 2021;49(W1):W431-W437. doi:10.1093/nar/gkab314. PMID:33956157. PMCID:PMC8262734.

PMID: 33956157
PMCID: PMC8262734
Funding: - Ministry of Education, Youth and Sports of the Czech Republic: LM2018131 - European Regional Development Fund: CZ.02.1.01/0.0/0.0/16_013/0001777 - Wellcome Trust: 104948 - National Science Foundation: DBI-1832184 - National Institutes of Health: R01GM133198 - U.S. Department of Energy: DE-SSC0019749

Documentation

Links