MonkeyCBP

MonkeyCBP performs connectivity-based parcellation of the monkey brain using structural neuroimaging to enable analysis of anatomical connectivity profiles in non-human primate neuroimaging, adapted from the ATPP (A Pipeline for Automatic Tractography-Based Brain Parcellation) framework.

Key Features:

• Species-Specific Adaptations: Adapts the ATPP framework to account for anatomical and functional differences between human and monkey brains.
• Brain Extraction: Employs enhanced brain extraction techniques tailored to accurately delineate monkey brain boundaries from imaging data.
• Image Registration: Implements customized image registration algorithms for precise alignment of monkey neuroimaging datasets.
• Validity Indices: Includes tailored validity indices to assess parcellation quality and accuracy specific to monkey brains.
• High-Throughput Computation: Supports efficient, large-scale processing for high-throughput connectivity-based analyses in non-human primate datasets.

Scientific Applications:

• Brain development studies: Uses connectivity-based parcellation to investigate developmental changes in monkey brain organization.
• Cognitive function mapping: Delineates connectivity-defined subregions to study neural substrates of cognitive functions in non-human primates.
• Psychiatric disorder models: Maps anatomical connectivity in monkey models to support research into psychiatric disorders.
• Region-specific connectomics: Enables detailed examination of regions such as the posterior cingulate cortex and frontal pole to characterize their anatomical connectivity.

Methodology:

Adaptation of the ATPP framework using structural neuroimaging data to derive anatomical connectivity profiles; application of advanced image processing for brain extraction and image registration; and implementation of specialized validity indices to evaluate parcellation outcomes.