Motif scraper
Motif scraper identifies degenerate nucleotide motifs in FASTA files to locate genomic features defined by non-exact sequence matches.
Key Features:
- Degenerate Motif Identification: Identifies degenerate nucleotide motifs that represent multiple compatible matches such as transcription factor binding sites.
- Versatility Across Genomes: Operates on any FASTA file, enabling motif discovery in model and non-model genomes and personal whole-genome sequences.
- Efficiency and Scalability: Utilizes a multiprocessor approach to accelerate motif searches for large datasets.
Scientific Applications:
- Transcription Factor Binding Site Analysis: Detects transcription factor motifs to support studies of gene regulation.
- Comparative Genomics: Enables comparison of motif occurrences between model and non-model species to inform evolutionary analyses.
- Personalized Genomics: Analyses individual whole-genome sequences to identify unique regulatory motifs or genetic markers.
Methodology:
Scans FASTA files for degenerate nucleotide motifs and utilizes a multiprocessor approach to enhance search efficiency.
Topics
Details
- License:
- MIT
- Tool Type:
- command-line tool
- Operating Systems:
- Linux, Mac
- Programming Languages:
- Python
- Added:
- 7/3/2018
- Last Updated:
- 11/25/2024
Operations
Publications
Roberson EDO. Motif scraper: a cross-platform, open-source tool for identifying degenerate nucleotide motif matches in FASTA files. Bioinformatics. 2018;34(22):3926-3928. doi:10.1093/bioinformatics/bty437. PMID:29850891. PMCID:PMC6223366.
PMID: 29850891
PMCID: PMC6223366
Funding: - National Institute of Arthritis and Musculoskeletal and Skin Diseases: P30-AR048335