Motif scraper

Motif scraper identifies degenerate nucleotide motifs in FASTA files to locate genomic features defined by non-exact sequence matches.


Key Features:

  • Degenerate Motif Identification: Identifies degenerate nucleotide motifs that represent multiple compatible matches such as transcription factor binding sites.
  • Versatility Across Genomes: Operates on any FASTA file, enabling motif discovery in model and non-model genomes and personal whole-genome sequences.
  • Efficiency and Scalability: Utilizes a multiprocessor approach to accelerate motif searches for large datasets.

Scientific Applications:

  • Transcription Factor Binding Site Analysis: Detects transcription factor motifs to support studies of gene regulation.
  • Comparative Genomics: Enables comparison of motif occurrences between model and non-model species to inform evolutionary analyses.
  • Personalized Genomics: Analyses individual whole-genome sequences to identify unique regulatory motifs or genetic markers.

Methodology:

Scans FASTA files for degenerate nucleotide motifs and utilizes a multiprocessor approach to enhance search efficiency.

Topics

Details

License:
MIT
Tool Type:
command-line tool
Operating Systems:
Linux, Mac
Programming Languages:
Python
Added:
7/3/2018
Last Updated:
11/25/2024

Operations

Publications

Roberson EDO. Motif scraper: a cross-platform, open-source tool for identifying degenerate nucleotide motif matches in FASTA files. Bioinformatics. 2018;34(22):3926-3928. doi:10.1093/bioinformatics/bty437. PMID:29850891. PMCID:PMC6223366.

PMID: 29850891
PMCID: PMC6223366
Funding: - National Institute of Arthritis and Musculoskeletal and Skin Diseases: P30-AR048335

Documentation