Mouse Genome Informatics

Mouse Genome Informatics integrates genetic, genomic, and biological data for the laboratory mouse to facilitate research on human health and disease.

Key Features:

• Integrated Data Federation: MGI federates expertly curated information from the Mouse Genome Database (MGD) and the Gene Expression Database (GXD), which share data and system architecture.
• Controlled Vocabulary Annotation: Biocuration scientists annotate data using terms from controlled metadata vocabularies and biological ontologies including Mammalian Phenotype Ontology, Mouse Developmental Anatomy, Disease Ontology, and Gene Ontology.
• Standardized Nomenclature: MGI applies international community standards for gene, allele, and mouse strain nomenclature to facilitate data integration and standardization.
• FAIR-Compliant Data Access: MGI provides access to FAIR-compliant data in both human-readable and compute-ready formats.
• Comprehensive Data Types: MGI integrates information about mouse genome features, variation, expression, gene function, phenotype, and human disease models.

Scientific Applications:

• Genetic and Genomic Research: MGI supports experimental and computational investigations into genetic and genomic aspects of human biology and disease using the laboratory mouse as a model system.
• Translational Research: MGI serves basic scientists, translational researchers, and data scientists investigating human disease models.
• Gene Expression Analysis: GXD enables research into gene expression patterns during mouse development.
• Phenotype-Disease Modeling: Researchers use MGI data to study phenotypes and their relationships to human diseases through controlled ontology annotations.

Methodology:

MGI acquires data from peer-reviewed publications, author submissions, and major bioinformatics resources, with biocuration scientists annotating using controlled vocabularies and biological ontologies and applying international community standards for nomenclature.