MPAD

MPAD aggregates experimental binding affinity data for membrane protein complexes and their mutants into a curated database supporting analysis of membrane protein-protein interactions and their determinants.

Key Features:

• Comprehensive data compilation: Aggregates experimental binding affinity measurements for membrane protein complexes and their mutants from published literature.
• Detailed information repository: Stores sequence information, structural details, functional annotations, membrane-specific features, and experimental conditions associated with each entry.
• Literature integration: Links each dataset to relevant literature references for contextual information and validation.

Scientific Applications:

• Understanding binding affinity factors: Enables comparison of factors influencing binding affinity in membrane proteins versus globular proteins.
• Impact of mutations: Supports studies of how mutations alter binding affinities and affect biological function and disease mechanisms.
• Structure-based drug design: Provides detailed complex and mutant data to inform structure-based drug design targeting membrane proteins.

Methodology:

Data were systematically compiled, curated, and organized from published literature to collect experimental binding affinities, sequences, structural and functional annotations, membrane-specific features, and experimental conditions for membrane protein complexes and their mutants.