MSABrowser

MSABrowser visualizes sequence alignments with overlaid genetic variations, post-translational modifications, and functional annotations to support interpretation of sequence-level functional and evolutionary relationships across DNA, RNA, and protein sequences.

Key Features:

• Co-visualization: Enables joint visualization of genetic variations, post-translational modifications, and annotations directly on sequence alignments to correlate data types with specific amino acids or nucleotides.
• Sequence-type mapping: Maps annotations, variants, and PTMs to DNA, RNA, and protein sequences at the nucleotide or amino-acid level within alignments.
• Implementation: Implemented in JavaScript and built on modern web technologies to render complex alignment visualizations efficiently.

Scientific Applications:

• Comparative Genomics: Identifies conserved regions and evolutionary relationships across organisms using aligned sequences and overlaid annotations.
• Protein Function Analysis: Highlights functionally important domains and post-translational modifications affecting protein activity or interactions within alignment context.
• Variant Annotation: Places genetic variations within alignments to assess impacts on gene function and disease association.

Methodology:

Implemented in JavaScript and leveraging modern web technologies for dynamic rendering of sequence alignments and annotation/variant/PTM overlays.