MS2Rescore

MS2Rescore increases peptide identifications in proteomics workflows through modular rescoring of peptide-spectrum matches (PSMs) from tandem mass spectrometry data.

Key Features:

• Modular Platform: MS2Rescore provides a versatile, modular architecture for rescoring PSMs with minimal installation effort across various platforms.
• MS Amanda 3.0 Integration: MS2Rescore connects with MS Amanda 3.0, utilizing additional output columns from the search engine for rescoring.
• Data-Driven Rescoring: The platform implements data-driven rescoring approaches that substantially increase PSMs on challenging data sets such as single-cell proteomics data.

Scientific Applications:

• Single-Cell Proteomics: MS2Rescore substantially increases peptide-spectrum matches on publicly available single-cell data sets.
• Tandem Mass Spectrometry Data Analysis: MS2Rescore serves as a standard procedure for rescoring PSMs in proteomics workflows.

Methodology:

MS2Rescore performs rescoring of peptide-spectrum matches (PSMs) from tandem mass spectrometry data using a modular platform approach.