MSV3d

MSV3d maps human missense variants onto three-dimensional protein structures to annotate physico-chemical changes and spatial functional context for assessing variant impact.

Key Features:

• Proteome Coverage: Annotations cover 20,199 human proteins.
• Detailed Annotation: Per-variant multi-level characterization includes physico-chemical changes resulting from amino acid substitutions.
• Conservation Analysis: Residue conservation status is provided to assess evolutionary preservation and potential deleterious effects.
• Functional Context Mapping: Variants are positioned relative to functional features within available or predicted 3D protein models to assess effects on interactions, active sites, and structural integrity.
• Regular Updates: Major releases are automatically generated aligned with updates from dbSNP and SwissVar using Décrypthon computational grid resources.

Scientific Applications:

• Genetic Research: Links genetic variations to structural changes to aid identification of potential disease-associated markers.
• Protein Engineering: Supports prediction of how amino acid substitutions may alter protein function for design of modified proteins.
• Pharmacogenomics: Informs prediction of variant impacts on protein structure and function to support personalized medicine and drug response studies.

Methodology:

Missense variants are mapped onto available or predicted 3D protein models; per-variant annotations include physico-chemical change characterization and residue conservation analysis; variants are positioned relative to functional features; major releases are synchronized with dbSNP and SwissVar via the Décrypthon computational grid.