MTB-Report

MTB-Report annotates, filters, and prioritizes genetic variants to support interpretation and identification of actionable targets for molecular tumor boards and precision oncology.

Key Features:

• Annotation, Filtering, and Sorting: Annotates genetic variants using comprehensive information from public databases and filters and sorts variants to highlight potentially actionable events.
• Dual Interface Modes: Provides web and command-line modes, with command-line support for batch processing of large datasets.
• Reproducibility and Stability: Implemented in R and distributed as a Docker image to enable reproducible execution across computing environments.

Scientific Applications:

• Precision Oncology: Streamlines analysis and prioritization of genomic variants to identify actionable therapeutic targets.
• Molecular Tumor Boards: Supports interpretation and reporting of genomic variant data for MTB workflows.
• Large-scale Genomic Studies: Enables batch processing and reproducible variant analysis across extensive datasets.

Methodology:

Annotation of genetic variants using public databases, filtering and sorting to prioritize actionable variants, implemented in R, distributed as a Docker image, and supporting web and command-line batch processing.