MTPpilot

MTPpilot facilitates visualization and interactive interpretation of next-generation sequencing (NGS) results to support precision oncology by assessing genomic alterations from comprehensive targeted NGS panels.

Key Features:

• Interactive visualization: Transforms complex text-based NGS gene panel results into dynamic visual formats for exploration and interpretation.
• Database integration: Integrates public genome, network, and cancer mutation databases for annotation and contextualization of variants.
• Functional impact assessment: Provides capabilities to assess the functional impact of detected mutations.
• Targeted NGS support: Handles comprehensive targeted NGS panels and large, complex panel data for molecular cancer diagnostics.
• Molecular tumor board support: Produces outputs suited to support clinical discussions at molecular tumor boards.
• Genomic alteration assessment: Aggregates multiple data sources to evaluate genomic alterations for clinical interpretation.

Scientific Applications:

• Molecular tumor board case review: Supports clinical discussions and case review at molecular tumor boards.
• Precision oncology diagnostics: Facilitates interpretation of targeted NGS panels for diagnostic and therapeutic decision-making in oncology.
• Treatment decision support: Aids determination of subsequent treatment options based on identified genomic alterations.
• Mutation interpretation and prioritization: Enables exploration and prioritization of mutations by assessing their functional impact.

Methodology:

Integration of public genome, network, and cancer mutation databases combined with interactive visualization of comprehensive targeted NGS gene panel results to assess the functional impact of detected mutations.