MulteeSum

MulteeSum integrates temporal dynamics and spatial cellular localization to visualize and support inspection and curation of gene expression datasets for single-cell and comparative developmental analyses.

Key Features:

• Temporal-Spatial Integration: Combines temporal gene-expression measurements with precise spatial cellular localization to represent dynamics of gene expression over developmental stages.
• Multi-Species Comparison: Enables comparison of gene expression datasets across multiple related species, including various subspecies of Drosophila, to reveal evolutionary and developmental differences.
• Flexible Framework: Supports multiple summaries per cell and enables computations that combine spatial data, temporal measurements, and cross-species information.

Scientific Applications:

• Developmental Biology: Visualizes gene expression in individual cells over time in systems such as fruitfly embryos to study developmental processes and cellular differentiation.
• Comparative Genomics: Facilitates identification of conserved and divergent gene expression patterns across related species for evolutionary and comparative studies.

Methodology:

Integrates per-cell temporal gene-expression summaries with spatial localization and supports comparative analyses across multiple species datasets, accepting multiple summaries per cell.